American Chemical Society
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Characterization of Dimeric Chiral Lithium Amide Structures Derived from N-isopropyl-O- triisopropylsilyl Valinol

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journal contribution
posted on 2011-05-04, 00:00 authored by Gerald Kagan, Weibin Li, Deyu Li, Russell Hopson, Paul G. Williard
The dimeric structure is characterized for a chiral amide base complex consisting of an (S)-N-isopropyl-O-triisopropylsilyl valinol ligand and lithium. The complex is characterized by a variety of NMR techniques, including multinuclear one- and two-dimensional NMR experiments and diffusion-ordered NMR spectroscopy (DOSY) as well as diffusion coefficient-formula weight (D-fw) correlation analyses. Spartan calculations are presented which support the structural assignment. This structural characterization leads to an explanation of the behavior and the reactivity of these complexes in solution.