Characteristics of the Two Frontier Orbital Interactions in the Diels−Alder Cycloaddition
journal contributionposted on 06.02.2004, 00:00 by Claude Spino, Hadi Rezaei, Yves L. Dory
Two electron-deficient dienes were reacted with a series of twelve electron-poor and electron-rich dienophiles to give, in some cases, the corresponding Diels−Alder adducts. Clear differences in the roles played by the two frontier orbital interactions emerged. It was demonstrated that in the case of normal Diels−Alder cycloadditions, the FMO theory could predict the relative reactivities between dienophiles, while in the case of inverse-electron demand Diels−Alder reactions, it could not. It was shown that the dissymmetry in electron-rich dienophiles increases their reactivities.