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Cerebrosides of the Halotolerant Fungus Alternaria raphani Isolated from a Sea Salt Field

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journal contribution
posted on 25.09.2009, 00:00 by Wenliang Wang, Yi Wang, Hongwen Tao, Xiaoping Peng, Peipei Liu, Weiming Zhu
In order to search for structurally novel and bioactive natural compounds from marine-derived fungi, a halotolerant fungal strain (THW-18) identified as Alternaria raphani was isolated from sediment collected in the Hongdao sea salt field. From the ethyl acetate extract of Alternaria raphani, three new cerebrosides, alternarosides A−C (13), and a new diketopiperazine alkaloid, alternarosin A (4), together with 15 known compounds were isolated and identified by spectroscopic and chemical methods, as well as X-ray crystal diffraction analysis. Compounds 14 showed weak antibacterial activity against Escherichia coli, Bacillus subtilis, and Candida albicans with MIC values ranging from 70 to 400 μM.