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Cerebrosides and 2-Pyridone Alkaloids from the Halotolerant Fungus Penicillium chrysogenum Grown in a Hypersaline Medium

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posted on 2011-05-27, 00:00 authored by Xiaoping Peng, Yi Wang, Kunlai Sun, Peipei Liu, Xia Yin, Weiming Zhu
Five new cerebrosides, chrysogesides A−E (15), and two new 2-pyridone alkaloids, chrysogedones A and B (6 and 7), were isolated from the fermentation broth of Penicillium chrysogenum PXP-55, a halotolerant fungus grown in a hypersaline medium. Among them, chrysogesides B−D (24) are the first cerebrosides that contain an unsaturated C19-fatty acid. Their structures were identified by spectroscopic and chemical methods, including CD spectroscopy as well as the modified Mosher’s method. Compound 2 showed antimicrobial activity against Enterobacter aerogenes with an MIC value of 1.72 μM.

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