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Cavity-Type DNA Origami-Based Plasmonic Nanostructures for Raman Enhancement

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journal contribution
posted on 16.06.2017, 00:00 by Mengzhen Zhao, Xu Wang, Shaokang Ren, Yikang Xing, Jun Wang, Nan Teng, Dongxia Zhao, Wei Liu, Dan Zhu, Shao Su, Jiye Shi, Shiping Song, Lihua Wang, Jie Chao, Lianhui Wang
DNA origami has been established as addressable templates for site-specific anchoring of gold nanoparticles (AuNPs). Given that AuNPs are assembled by charged DNA oligonucleotides, it is important to reduce the charge repulsion between AuNPs–DNA and the template to realize high yields. Herein, we developed a cavity-type DNA origami as templates to organize 30 nm AuNPs, which formed dimer and tetramer plasmonic nanostructures. Transmission electron microscopy images showed that high yields of dimer and tetramer plasmonic nanostructures were obtained by using the cavity-type DNA origami as the template. More importantly, we observed significant Raman signal enhancement from molecules covalently attached to the plasmonic nanostructures, which provides a new way to high-sensitivity Raman sensing.

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