American Chemical Society
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Cationic Ionic Liquids Organic Ligands Based Metal–Organic Frameworks for Fabrication of Core–Shell Microspheres for Hydrophilic Interaction Liquid Chromatography

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journal contribution
posted on 2016-08-02, 00:00 authored by Qian Dai, Junqian Ma, Siqi Ma, Shengyu Wang, Lijun Li, Xianghui Zhu, Xiaoqiang Qiao
In this study, new metal–organic frameworks (MOFs) nanocrystals modified SiO2 core–shell microspheres were designed with cationic ionic liquids (ILs) 1,3-bis­(4-carboxybutyl)­imidazolium bromide (ILI) as organic ligands. By further adjustment the growth cycles, the new ILI-01@SiO2 core–shell stationary phase was facilely fabricated. The developed stationary phase was respectively characterized via element analysis, thermogravimetric analysis, scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectrometry. Because the introduction of cationic imidazolium-based ILs ILI for fabrication of the MOFs nanocrystals shell, the new stationary phase exhibits the retention mechanism of hydrophilic interaction liquid chromatography (HILIC). Many polar samples, such as amides, vitamins, nucleic acid bases, and nucleosides, were utilized to investigate the performance of the prepared ILI-01@SiO2 column. Compared to the conventional aminosilica column, the new ILI-01@SiO2 column displays high separation selectivity in a shorter separation time. Furthermore, the new ILI-01@SiO2 column was also used for detection of illegal melamine addition in the baby formula. All the above results demonstrate the new ILI-01@SiO2 core–shell stationary phase is of good potentials for high-selectivity separation the polar samples.