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Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium

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journal contribution
posted on 21.08.2018, 19:43 by Shotaro Hoshino, Masahiro Ozeki, Takayoshi Awakawa, Hiroyuki Morita, Hiroyasu Onaka, Ikuro Abe
The production of two new heterocyclic peptide isomers, catenulobactins A (1) and B (2), in cultures of Catenuloplanes sp. RD067331 was significantly increased when it was cocultured with a mycolic acid-containing bacterium. The planar structures and absolute configurations of the catenulobactins were determined based on NMR/MS and chiral-phase GC-MS analyses. Catenulobactin B (2) displayed Fe­(III)-chelating activity and moderate cytotoxicity against P388 murine leukemia cells.