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Catalytic atropo-Enantioselective Reduction of Biaryl Lactones to Axially Chiral Biaryl Compounds

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journal contribution
posted on 19.06.2008, 00:00 by Tomoko Ashizawa, Saiko Tanaka, Tohru Yamada
The atropo-enantioselective borohydride reduction with dynamic kinetic resolution of biaryl lactones was catalyzed by an optically active β-ketoiminatocobalt(II) complex to afford optically active biaryl compounds. Chiral HPLC analysis of the starting biaryl lactones was performed at various temperatures to determine suitable reaction conditions for dynamic kinetic resolution. Various types of axially chiral biaryl compounds were obtained with high enantioselectivity.