posted on 2019-05-03, 00:00authored byDanny
C. Lenstra, Joris J. Wolf, Jasmin Mecinović
We
report an efficient catalytic Staudinger reduction at room temperature
that enables the preparation of a structurally diverse set of amines
from azides in excellent yields. The reaction is based on the use
of catalytic amounts of triphenylphosphine as a phosphine source and
diphenyldisiloxane as a reducing agent. Our catalytic Staudinger reduction
exhibits a high chemoselectivity, as exemplified by reduction of azides
over other common functionalities, including nitriles, alkenes, alkynes,
esters, and ketones.