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Catalytic Hydrothiolation: Regio- and Enantioselective Coupling of Thiols and Dienes
journal contribution
posted on 2018-08-09, 18:49 authored by Xiao-Hui Yang, Ryan T. Davison, Vy M. DongWe report a Rh-catalyzed hydrothiolation
of 1,3-dienes, including
petroleum feedstocks. Either secondary or tertiary allylic sulfides
can be generated from the selective addition of a thiol to the more
substituted double bond of a diene. The catalyst tolerates a wide
range of functional groups, and the loading can be as low as 0.1 mol
%.