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Catalytic Hydroamination of Unactivated Olefins Using a Co Catalyst for Complex Molecule Synthesis

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journal contribution
posted on 01.10.2014, 00:00 by Hiroki Shigehisa, Natsumi Koseki, Nao Shimizu, Mayu Fujisawa, Makoto Niitsu, Kou Hiroya
Functional group tolerance is one of the important requirements for chemical reactions, especially for the synthesis of complex molecules. Herein, we report a mild, general, and functional group tolerant intramolecular hydroamination of unactivated olefins using a Co­(salen) complex, an N-fluoropyridinium salt, and a disiloxane reagent. This method, which was carried out at room temperature (or 0 °C), afforded three-, five-, six-, and seven-membered ring nitrogen-containing heterocyclic compounds and was compatible with diverse functional groups.