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Catalytic Friedel–Crafts Alkylation of Electron Rich Aromatic Derivatives with α‑Aryl Diazoacetates Mediated by Brønsted Acids

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journal contribution
posted on 04.03.2020, 22:29 by Rafael D. C. Gallo, Patrícia B. Momo, David P. Day, Antonio C. B. Burtoloso
The catalytic protonation of aryl diazoacetates by strong Brønsted acids, followed by a Friedel–Crafts alkylation reaction with electron rich aromatic compounds, is reported. The reaction provided in a direct fashion 24 geminal diarylacetates in yields of ≤92%.