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Catalytic Direct α‑Amination of Arylacetic Acid Synthons with Anilines

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journal contribution
posted on 01.10.2020, 01:43 by Jogendra Kumar, Eringathodi Suresh, Sukalyan Bhadra
A unique α-amination approach using various anilines has been developed for arylacetic acids via adaptation as benzazoles. The reaction proceeds through a single electron transfer mechanism utilizing an iron-based catalyst system to access α-(N-arylamino)­acetic acid equivalents. Modification of approved drugs, facile cleavage of the benzazole auxiliary, and tolerance of amide linkage forming conditions constitute the potential applicability of this strategy.

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