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Catalytic Asymmetric Total Synthesis of (+)-Yohimbine

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journal contribution
posted on 06.03.2008, 00:00 by Dustin J. Mergott, Stephan J. Zuend, Eric N. Jacobsen
The total synthesis of (+)-yohimbine was achieved in 11 steps and 14% overall yield. The absolute configuration was established through a highly enantioselective thiourea-catalyzed acyl-Pictet−Spengler reaction, and the remaining 4 stereocenters were set simultaneously in a substrate-controlled intramolecular Diels−Alder reaction.