ol2c00905_si_001.pdf (12.35 MB)
Catalytic, Asymmetric Total Synthesis of (+)-α‑, (+)-β‑, (+)-γ‑, and (−)-δ-Lycorane
journal contribution
posted on 2022-04-12, 14:12 authored by Tian-Yuan Zhang, Lu-Yue Zhang, Xiao Liang, Kun Wei, Yu-Rong YangThe first collectively asymmetric
total synthesis of all members
of lycorane, including (+)-α, (+)-β, (+)-γ, and
(−)-δ, in a catalytic manner has been achieved. The cornerstone
of this synthesis features an asymmetric, stereodivergent Ir/amine
dual catalytic α-allylation of 2-phthalimidoacetaldehyde.
