American Chemical Society
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Catalytic, Asymmetric Total Synthesis of (+)-α‑, (+)-β‑, (+)-γ‑, and (−)-δ-Lycorane

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journal contribution
posted on 2022-04-12, 14:12 authored by Tian-Yuan Zhang, Lu-Yue Zhang, Xiao Liang, Kun Wei, Yu-Rong Yang
The first collectively asymmetric total synthesis of all members of lycorane, including (+)-α, (+)-β, (+)-γ, and (−)-δ, in a catalytic manner has been achieved. The cornerstone of this synthesis features an asymmetric, stereodivergent Ir/amine dual catalytic α-allylation of 2-phthalimidoacetaldehyde.