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Catalytic Asymmetric Formal Aza-Diels–Alder Reactions of α,β-Unsaturated Ketones and 3H‑Indoles

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journal contribution
posted on 05.06.2015, 00:00 by Haoxiang Hu, Chunna Meng, Yun Dong, Xin Li, Jinxing Ye
Asymmetric formal aza-Diels–Alder reactions with α,β-unsaturated ketones and 3H-indoles with disubstituted groups on the C3 position catalyzed by primary amine-thiourea bifunctional catalyst have been developed. The reactions produced chiral hexahydropyrido-[1,2-a]-indole-2-ones in high yields with excellent diastereo- and enantioselectivities.