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Catalytic Asymmetric [3 + 2] Annulation of Hantzsch Esters with Racemic N‑Sulfonylaziridines

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journal contribution
posted on 05.10.2021, 15:16 by Guo-Sheng Zhu, Pei-Jun Yang, Chen-Xue Ma, Gaosheng Yang, Zhuo Chai
Hantzsch esters (HEs) served as two-carbon partners in a copper­(I)-catalyzed enantioselective [3 + 2] annulation with racemic 2-(hetero)­aryl-N-sulfonyl aziridines via kinetic resolution to provide pyrrolo­[2,3-b]­tetrahydropyridines containing multiple contiguous stereogenic centers including all-carbon quaternary centers in excellent yields and enantiopurities and moderate-to-excellent diastereoselectivities. Mainly dependent upon the structures of the aziridines, a competitive hydrogenolysis process with HEs as the hydrogen source was also observed in some cases.

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