American Chemical Society
ol403131t_si_001.pdf (3.87 MB)

Catalytic Antioxidants: Regenerable Tellurium Analogues of Vitamin E

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journal contribution
posted on 2015-12-17, 00:07 authored by Vijay P. Singh, Jia-fei Poon, Lars Engman
In an effort to improve the chain-breaking capacity of the natural antioxidants, an octyltelluro group was introduced next to the phenolic moiety in β- and δ-tocopherol. The new vitamin E analogues quenched peroxyl radicals more efficiently than α-tocopherol and were readily regenerable by aqueous N-acetylcysteine in a simple membrane model composed of a stirring chlorobenzene/water two-phase system. The novel tocopherol analogues could also mimic the action of the glutathione peroxidase enzymes.