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Catalyst-Free Annulation of 2‑Pyridylacetates and Ynals with Molecular Oxygen: An Access to 3‑Acylated Indolizines

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journal contribution
posted on 04.01.2019, 00:00 by Zhengwang Chen, Pei Liang, Xiaoyue Ma, Haiqing Luo, Guohai Xu, Tanggao Liu, Xiaowei Wen, Jing Zheng, Hui Ye
A catalyst and additive-free annulation of 2-pyridylacetates and ynals under molecular oxygen was the first developed, affording 3-acylated indolizines in good to excellent yields. Molecular oxygen was used as the source of the carbonyl oxygen atom in indolizines. This approach was compatible with a wide range of functional groups, and especially it has been successfully extended to unsaturated double bonds and triple bonds, which were difficult to prepare by previous methods in a single step.