Catalyst-Controlled Switch in Diastereoselectivities: Enantioselective Construction of Functionalized 3,4-Dihydro‑2H‑thiopyrano­[2,3‑b]­quinolines with Three Contiguous Stereocenters

A tandem Michael–Henry reaction of 2-mercapto­quinoline-3-carbaldehydes with nitroolefins using hydrogen-bonding-based cooperative organocatalysts for the highly diastereodivergent synthesis of chiral functionalized 3,4-dihydro-2H-thiopyrano­[2,3-b]­quinolines with three contiguous tertiary stereocenters has been developed.