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Cascade C–H Activation/Annulation of Sulfoxonium Ylides with Vinyl Cyclopropanes: Access to Cyclopropane-Fused α‑Tetralones

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posted on 2023-05-04, 16:05 authored by Sharajit Saha, Bijoy Debnath, Kangkan Talukdar, Pallab Karjee, Santu Mandal, Tharmalingam Punniyamurthy
Rh-catalyzed weak and traceless directing-group-assisted cascade C–H activation and annulation of sulfoxonium ylides with vinyl cyclopropanes as a coupling partner have been accomplished to furnish functionalized cyclopropane-fused tetralones at moderate temperature. The C–C bond formation, cyclopropanation, functional group tolerance, late-stage diversifications of drug molecules, and scale-up are the important practical features.

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