ol062031q_si_001.pdf (2.43 MB)
Download fileCarboxylic Acid Catalyzed Three-Component Aza-Friedel−Crafts Reactions in Water for the Synthesis of 3-Substituted Indoles
journal contribution
posted on 2006-10-12, 00:00 authored by Seiji Shirakawa, Shū KobayashiThe carboxylic acid catalyzed three-component aza-Friedel−Crafts reactions of aldehydes, primary amines, and indoles in water have been
developed. The aza-Friedel−Crafts products could be easily transformed to various 3-substituted indoles including biologically active compounds.
This system offers a novel efficient method for the synthesis of 3-substituted indoles.