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Carbon Dioxide as the C1 Source for Direct C−H Functionalization of Aromatic Heterocycles

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journal contribution
posted on 06.08.2010, 00:00 by Oleg Vechorkin, Nathalie Hirt, Xile Hu
A simple and straightforward method has been developed for the direct carboxylation of aromatic heterocylces such as oxazoles, thiazoles, and oxadiazoles using CO2 as the C1 source. The reactions require no metal catalyst and only Cs2CO3 as the base. A good functional group tolerance is achieved.