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Carbohydrate-Derived Amino-Alcohol Ligands for Asymmetric Alkynylation of Aldehydes

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journal contribution
posted on 19.01.2006, 00:00 by Daniel P. G. Emmerson, William P. Hems, Benjamin G. Davis
Conformationally restricted amino alcohols based on carbohydrate scaffolds provide flexible and fine-tuneable libraries that greatly expand the range of ligands available in the Zn(OTf)2-mediated addition of alkynes to aldehydes, in some cases with very high stereoselectivities.