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Carbacaprazamycins: Chemically Stable Analogues of the Caprazamycin Nucleoside Antibiotics

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journal contribution
posted on 10.04.2015, 00:00 by Satoshi Ichikawa, Mayumi Yamaguchi, Lee Shang Hsuan, Yuta Kato, Akira Matsuda
Carbacaprazamycins, which are chemically stable analogues of caprazamycins, were designed and synthesized. These analogues were active against drug-resistant bacterial pathogens such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci, and their activities were comparable to those of the parent caprazamycins. The effect of treatment with carbacaprazamycin on morphological changes in S. aureus indicated that the mode of action was completely different from those of existing peptidoglycan inhibitors.