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C–H Activation/Functionalization Catalyzed by Simple, Well-Defined Low-Valent Cobalt Complexes

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journal contribution
posted on 25.02.2015, 00:00 by Brendan J. Fallon, Etienne Derat, Muriel Amatore, Corinne Aubert, Fabrice Chemla, Franck Ferreira, Alejandro Perez-Luna, Marc Petit
A facile C–H activation and functionalization of aromatic imines is presented using low-valent cobalt catalysts. Using Co­(PMe3)4 as catalyst we have developed an efficient and simple protocol for the C–H/hydroarylation of alkynes with an anti selectivity. Deuterium-labeling experiments, DFT calculations coupled with the use of a well-defined catalyst have for the first time shed light on the elusive black box of cobalt catalyzed C–H functionalization.

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