posted on 2017-01-18, 00:00authored byCheng-Qiang Wang, Lu Ye, Chao Feng, Teck-Peng Loh
Using α,α-difluoromethylene
alkyne as a nontraditional
one-carbon reaction partner, a synthetically novel method for the
construction of isoindolin-1-one derivatives via Rh(III)-catalyzed
[4+1] annulation reaction is reported. The 2-fold C–F bond
cleavage not only enables the generation of desired product under
an overall oxidant-free condition but also results in a net migration
of carbon–carbon triple bond. In addition, the present reaction
protocol exhibits a tolerance of a wide spectrum of functional groups
due to the mild reaction conditions employed.