posted on 2001-01-25, 00:00authored byJon D. Rainier, Shawn P. Allwein, Jason M. Cox
This paper describes a formal total synthesis of the marine ladder toxin hemibrevetoxin B from
Danishefsky's dienes. This approach couples the generation of C-glycosides from cyclic enol ethers
with metathesis or acid-mediated annulation reactions. The result is a highly efficient synthesis of
the tetracyclic ring system of hemibrevetoxin B.