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Busseihydroquinones A–D from the Roots of Pentas bussei

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journal contribution
posted on 27.07.2012, 00:00 by Milkyas Endale, Annabel Ekberg, Hoseah M. Akala, John Patrick Alao, Per Sunnerhagen, Abiy Yenesew, Máté Erdélyi
Four new naphthohydroquinones, named busseihydroquinones A–D (14), along with a known homoprenylated dihydronaphthoquinone (5), were isolated from the CH2Cl2/MeOH (1:1) extract of the roots of Pentas bussei. Although the genus Pentas is frequently used by traditional healers for the treatment of malaria, only marginal activities against the chloroquine-sensitive (D6) and the chloroquine-resistant (W2) strains of Plasmodium falciparum were observed for the crude root extract and the isolated constituents of this plant.