Burkholdines 1097 and 1229, Potent Antifungal Peptides from Burkholderia ambifaria 2.2N

Tawfik, Kamilia A.; Jeffs, Peter; Bray, Brian; Dubay, George; Falkinham, Joseph O.; Mesbah, Mostafa; Youssef, Diaa; Khalifa, Sherief; Schmidt, Eric W.

doi:10.1021/ol9029269.s001

Burkholdines 1097 and 1229, Potent Antifungal Peptides from Burkholderia ambifaria 2.2N

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posted on 2010-02-19, 00:00 authored by Kamilia A. Tawfik, Peter Jeffs, Brian Bray, George Dubay, Joseph O. Falkinham, Mostafa Mesbah, Diaa Youssef, Sherief Khalifa, Eric W. Schmidt

Potent antifungal cyclic lipopeptides, burkholdines (Bk), were isolated from a culture of Burkholderia ambifaria 2.2N. Bk-1229 (1) and Bk-1097 (2) are octapeptides comprised of nonproteinogenic amino acids, including β-hydroxytyrosine, β-hydroxyasparagine, and a new fatty acyl amino acid. 1 and 2 are fungicidal against a panel of fungi with potencies 2−60-fold better than amphotericin B control.

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acid Bk Burkholdines 1097 Burkholderia ambifaria 2.2 N Burkholderia ambifaria 2.2 N Potent antifungal cyclic lipopeptides amphotericin B control

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Burkholdines 1097 and 1229, Potent Antifungal Peptides from Burkholderia ambifaria 2.2N

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