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Broadening the Scope of Steroidal Scaffolds: The Umpolung of a Bis-Primary Amine Precatalyst for the Insertion of CO2 into Epoxides

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journal contribution
posted on 21.08.2020, 14:34 authored by Noé Fanjul-Mosteirín, Judith Martín, Carlos Valdés, Carmen Concellón, Vicente del Amo
A cholic acid-based bis-primary amine is capable of promoting the insertion of CO2 into epoxides with the cooperative aid of an iodide anion. This framework is transformed in situ into a bis-carbamic acid. The latter is the active catalytic species, operating through H-bonding interactions. Our system works with complete atom economy, under solvent-free, metal-free, and mild conditions. Also, it can be recycled.