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Brønsted Acid Catalyzed Asymmetric Aldol Reaction: A Complementary Approach to Enamine Catalysis

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journal contribution
posted on 20.08.2010, 00:00 by Guillaume Pousse, Fabien Le Cavelier, Luke Humphreys, Jacques Rouden, Jérôme Blanchet
A syn-enantioselective aldol reaction has been developed using Brønsted acid catalysis based on H8-BINOL-derived phosphoric acids. This method affords an efficient synthesis of various β-hydroxy ketones, some of which could not be synthesized using enamine organocatalysis.