Brønsted Acid-Catalyzed Minisci-Type Cross-Dehydrogenative Coupling of N‑Heteroaromatics and Cyclic Ethers

Brønsted acid-catalyzed direct C­(sp²)–H alkylation of N-heteroaromatics with cyclic ethers via a cross-dehydrogenative coupling reaction in the presence of benzoyl peroxide was developed. This methodology successfully provided an easy access to a variety of alkyl-substituted quinoxaline, benzoimidazole, pyrazine, pyrimidine, quinoline, isoquinoline, and pyridine derivatives in up to 94% yield under metal-free conditions.