Bottlebrush-Colloid Janus Nanoparticles

A bottlebrush-colloid Janus nanoparticle (JNP) with a ball-and-stick structure is reported. A single poly­(4-vinyl benzyl chloride) (PVBC) polymer chain was grafted onto the amine-capped Fe₃O₄@NH₂ nanoparticle. pH-responsive 2-diethylaminoethyl methacrylate (DEAEMA) and water-soluble oligo­(ethylene glycol) methacrylate (OEGMA) were sequentially grown from the PVBC backbone by ATRP, forming a core–shell bottlebrush. The synthesized PVBC₂₀₈-g-(PDEAEMA₁₃-b-POEGMA₈)-Fe₃O₄@NH₂ JNPs are dispersible in water and can be manipulated by a magnet. The Fe₃O₄ NPs with exposed −NH₂ groups facilitate accumulation at acidic sites. Hydrophobic dyes can be loaded within the PDEAEMA at pH ≥ 7.5, while they are released at pH values below 6.8. The composite JNPs are promising as a guided pH-responsive delivery vector toward acidic solid tumors.