American Chemical Society
ol3c03257_si_002.pdf (1.14 MB)

Boron Triiodide-Mediated Reduction of Nitroarenes Using Borohydride Reagents

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journal contribution
posted on 2023-12-05, 21:31 authored by Andrej Ćorković, Thomas Chiarella, Florence J. Williams
The reduction of nitroarenes using KBH4 and I2 is described. BI3 is generated in situ and was shown to be the active reductant. Conditions were optimized for BI3 generation and then applied to a wide range of nitroarenes, including traditionally challenging substrates. The method constitutes a practical reduction option which produces low-toxicity boric acid and potassium iodide upon workup.