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Biselyngbyaside, a Macrolide Glycoside from the Marine Cyanobacterium Lyngbya sp.

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journal contribution
posted on 04.06.2009, 00:00 by Toshiaki Teruya, Hiroaki Sasaki, Kazuhiro Kitamura, Takeshi Nakayama, Kiyotake Suenaga
Bioassay-guided fractionation of the cytotoxic constituents of the marine cyanobacterium Lyngbya sp. led to the isolation of biselyngbyaside (1), a new 18-membered macrolide glycoside. The structure of 1 was established by spectroscopic analysis including 2D-NMR techniques and by synthetic studies. Biselyngbyaside (1) exhibits broad-spectrum cytotoxicity in a human tumor cell line panel.