posted on 2012-07-06, 00:00authored byBeatriz Angulo, José I. García, Clara I. Herrerías, José A. Mayoral, Ana C. Miñana
An efficient release–capture strategy for the
recovery and
reuse of enantioselective catalysts in the Henry reaction is described.
This strategy is based on the precipitation of an insoluble coordination
polymer at the end of each reaction, allowing easy separation from
products. The coordination polymer is formed through aggregation of
Cu(II) ions with ditopic bisoxazoline-based chiral ligands. Up to
11 catalytic cycles have been conducted keeping good yields and enantioselectivities.