American Chemical Society
ol4015706_si_001.pdf (2.62 MB)

Biomimetic Synthesis of ent-(−)-Azonazine and Stereochemical Reassignment of Natural Product

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journal contribution
posted on 2013-09-06, 00:00 authored by Ji-Chen Zhao, Shun-Ming Yu, Yun Liu, Zhu-Jun Yao
The first total synthesis of ent-(−)-azonazine has been accomplished using a hypervalent iodine-mediated biomimetic oxidative cyclization to construct the highly strained core. Based on the results from the completed synthesis, both the relative and absolute configurations of natural (+)-azonazine were revised.