ab0c00443_si_001.pdf (2.44 MB)
Biomimetic Gelatin Methacrylate/Nano Fish Bone Hybrid Hydrogel for Bone Regeneration via Osteoimmunomodulation
journal contribution
posted on 2020-05-21, 15:40 authored by Liping Huang, Jianhua Zhang, Junfei Hu, Tianbao Zhao, Zhipeng GuThe consideration
of osteoimmunomodulatory activity is crucial
to determine the in vivo fate of the bone biomaterials.
Herein, we proposed a biomimetic gelatin methacrylate/nano fish bone
hybrid hydrogel to systematically investigate its potential for bone
regeneration. The results showed that nano fish bone incorporation
could not only enhance the mechanical performance of hybrid hydrogel
but also modulate the immune microenvironment to further promote bone
regeneration. This nano fish bone-based hybrid hydrogel would provide
a promising option for developing advanced bone biomaterials with
osteoimmunomodulatory activities.