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Biodegradable π‑Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics

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journal contribution
posted on 08.11.2019, 22:43 by Xiaozhen Li, Lu Liu, Shengliang Li, Yingpeng Wan, Jia-Xiong Chen, Shuang Tian, Zhongming Huang, Ya-Fang Xiao, Xiao Cui, Chengyang Xiang, Qinglong Tan, Xiao-Hong Zhang, Weisheng Guo, Xing-Jie Liang, Chun-Sing Lee
We developed a biodegradable photothermal therapeutic (PTT) agent, π-conjugated oligomer nanoparticles (F8-PEG NPs), for highly efficient cancer theranostics. By exploiting an oligomer with excellent near-infrared (NIR) absorption, the nanoparticles show a high photothermal conversion efficiency (PCE) up to 82%, surpassing those of reported inorganic and organic PTT agents. In addition, the oligomer nanoparticles show excellent photostability and good biodegradability. The F8-PEG NPs are also demonstrated to have excellent biosafety and PTT efficacy both in vitro and in vivo. This contribution not only proposes a promising oligomer-based PTT agent but also provides insight into developing highly efficient nanomaterials for cancer theranostics.