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Bioactive Scalaranes from the Thai Sponge Hyrtios gumminae

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journal contribution
posted on 23.10.2009, 00:00 by Chulabhorn Mahidol, Hunsa Prawat, Suwannee Sangpetsiripan, Somsak Ruchirawat
Chemical investigation of the Thai sponge Hyrtios gumminae collected from Similan Island in the Andaman Sea, Thailand, yielded four new sesterterpenoids, similan A (1), 12β,20-dihydroxy-16β-acetoxy-17-scalaren-19,20-olide (2), 12β-acetoxy-20-hydroxy-17-scalaren-19,20-olide (3), and 12β,16α,20-trihydroxy-17-scalaren-19,20-olide (4), together with seven known compounds. The structures of these new compounds were elucidated on the basis of their spectroscopic data and chemical transformations. Some of the isolated compounds were tested for their cytotoxic activity.