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Bioactive Phenylpropanoids from Daucus crinitus Desf. from Algeria

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journal contribution
posted on 24.02.2010, 00:00 authored by Don-Antoine Lanfranchi, Hocine Laouer, Meriem El Kolli, Soizic Prado, Christine Maulay-Bailly, Nicolas Baldovini
The volatile constituents of Daucus crinitus Desf. from Algeria were analyzed by GC and GC-MS, The main constituent was isochavicol isobutyrate (39.0%), an uncommon phenylpropanoid. By synthesis of a series of homologous esters, it was also possible to determine the presence of small amounts of isochavicol propionate, which has never been described previously as a natural product. The antibacterial and antifungal activities of the whole essential oil, of these two esters, and of isochavicol itself were investigated against a wide range of bacteria and fungi. Additionally, their antimalarial and antiradical properties were also evaluated, showing an interesting antiplasmodial activity of isochavicol.

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