np5b01126_si_001.pdf (6.86 MB)
Download fileBioactive Iridoid Glycosides from the Whole Plants of Rehmannia chingii
journal contribution
posted on 2016-02-09, 00:00 authored by Yan-Fei Liu, Guo-Ru Shi, Xin Wang, Chun-Lei Zhang, Yan Wang, Ruo-Yun Chen, De-Quan YuNine new iridoid glycosides, rehmachingiiosides
A–I
(1–9), together with 16 known analogues,
were isolated from the whole plants of Rehmannia chingii. The structures of compounds 1–9 were elucidated on the basis of spectroscopic data analysis and
from chemical evidence. Furthermore, in two vitro assays, compounds 5 and 10 showed an inhibitory effect on LPS-induced
NO production with IC50 values of 2.5 and 7.3 μM,
and compounds 4, 6, and 10–12 (when evaluated at 10 μM) exhibited evidence of hepatoprotective
effects against APAP-induced HepG2 cell damage.