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Bioactive Iridoid Glycosides from the Whole Plants of Rehmannia chingii

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journal contribution
posted on 2016-02-09, 00:00 authored by Yan-Fei Liu, Guo-Ru Shi, Xin Wang, Chun-Lei Zhang, Yan Wang, Ruo-Yun Chen, De-Quan Yu
Nine new iridoid glycosides, rehmachingiiosides A–I (19), together with 16 known analogues, were isolated from the whole plants of Rehmannia chingii. The structures of compounds 19 were elucidated on the basis of spectroscopic data analysis and from chemical evidence. Furthermore, in two vitro assays, compounds 5 and 10 showed an inhibitory effect on LPS-induced NO production with IC50 values of 2.5 and 7.3 μM, and compounds 4, 6, and 1012 (when evaluated at 10 μM) exhibited evidence of hepatoprotective effects against APAP-induced HepG2 cell damage.