Bioactive Compounds from Combretum erythrophyllum
journal contributionposted on 17.03.2000, 00:00 by Sianne Schwikkard, Bing-Nan Zhou, Thomas E. Glass, Jessica L. Sharp, Michael R. Mattern, Randall K. Johnson, David G. I. Kingston
A methanol extract of Combretum erythrophyllum showed inhibitory bioactivities in a yeast-based microtiter assay for DNA-damaging agents. Bioassay-guided fractionation of this extract yielded two known bioactive compounds, combretastatin A-1 and (−)-combretastatin, and two new bioactive glucosides, combretastatin A-1 2‘-β-d-glucoside (1) and combretastatin B-1 2‘-β-d-glucoside (2). The structures of the new compounds were assigned by 1H and 13C NMR, DEPT, HMQC, and HMBC spectra.