Bioactive Components of Polyphenol-Rich
and Non-Polyphenol-Rich
Cranberry Fruit Extracts and Their Chemopreventive Effects on Colitis-Associated
Colon Cancer
posted on 2020-06-05, 12:04authored byXian Wu, Liang Xue, Anuradha Tata, Mingyue Song, Catherine C. Neto, Hang Xiao
Cranberries contain various constituents
relevant to human health.
Our previous study demonstrated the chemopreventive effects of whole
cranberry against colon cancer in mice. In order to determine the
role of different cranberry secondary metabolites in inhibiting colon
cancer, cranberry ethyl acetate extract (EAE) and polyphenol extract
(PPE) were obtained. The free-radical scavenging activities and chemical
composition of the cranberry extracts were determined. EAE consisted
of triterpenes and sterols and a trace amount of proanthocyanidins.
PPE mainly contained polyphenol with a trace amount of triterpenes.
The chemopreventive effects of orally administered EAE and PPE on
colitis-associated colon carcinogenesis were determined in mice. Dietary
EAE and PPE significantly suppressed tumor metrics without noticeable
adverse effects. Gene expression levels of key proinflammatory cytokines
were also attenuated by EAE and PPE in the mouse colon. In conclusion,
the novel cranberry extracts may offer an efficacious and safe means
to prevent colonic tumorigenesis in humans.