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Bioactive Asterric Acid Derivatives from the Antarctic Ascomycete Fungus Geomyces sp.

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journal contribution
posted on 26.09.2008, 00:00 authored by Yan Li, Bingda Sun, Shuchun Liu, Lihua Jiang, Xingzhong Liu, Hua Zhang, Yongsheng Che
Five new asterric acid derivatives, ethyl asterrate (3), n-butyl asterrate (4), and geomycins A−C (68), have been isolated from cultures of an isolate of the Antarctic ascomycete fungus Geomyces sp. The structures of these metabolites were elucidated by NMR spectroscopy. The absolute configuration of 8 was determined by application of the CD excitation chirality method. Compound 7 displayed antifungal activity against Aspergillus fumigatus, whereas 8 showed antimicrobial activities against Gram-positive and Gram-negative bacteria.