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Bilayer Properties of 1,3-Diamidophospholipids

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journal contribution
posted on 17.02.2015, 00:00 by Andreas Weinberger, Radu Tanasescu, Cristina Stefaniu, lllya A. Fedotenko, France Favarger, Takashi Ishikawa, Gerald Brezesinski, Carlos M. Marques, Andreas Zumbuehl
A series of 1,3-diamido phosphocholines was synthesized, and their potential to form stable bilayers was investigated. Large and giant unilamellar vesicles produced from these new lipids form a wide variety of faceted liposomes. Factors such as cooling rates and the careful choice of the liposome preparation method influence the formation of facets. Interdigitation was hypothesized as a main factor for the stabilization of facets and effectively monitored by small-angle X-ray scattering measurements.