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Bicyclic Piperidines via [2 + 2] Photocycloaddition

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journal contribution
posted on 19.11.2020, 19:34 by Valeriya Shcherbakova, Dmitry Dibchak, Mariya Snisarenko, Yevhen Skalenko, Aleksandr V. Denisenko, Anastasiia S. Kuznetsova, Pavel K. Mykhailiuk
A synthetic strategy to fused bicyclic piperidinesbuilding blocks for medicinal chemistryis developed. The key step was an intramolecular [2 + 2]-photocyclization. The photochemical step was performed on a gram scale. Crystallographic analysis of the obtained compounds revealed that they occupy a novel chemical space and can be considered as elongated analogues of 3-substituted piperidines.