American Chemical Society
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Biaryl Formation via Base-Promoted Direct Coupling Reactions of Arenes with Aryl Halides

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journal contribution
posted on 2021-06-09, 08:14 authored by Muhammad Asif Iqbal, Le Lu, Hina Mehmood, Ruimao Hua
In the absence of ligand, Cs2CO3-promoted cross-coupling reaction of arenes with cyano-/nitro-substituted aryl halides in DMSO affording biaryls is reported. The cyano/nitro group in biaryls is useful and convenient for further transformation. The formation of dibenzofurans resulting from the reactions between arenes and 1-bromo-2-iodobenzene is also reported. On the basis of control experiments and theoretical studies, a radical mechanism is proposed for the formation of biaryls.