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Benzotriazole as an Efficient Ligand in Cu-Catalyzed Glaser Reaction

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journal contribution
posted on 31.01.2019, 00:00 by Mala Singh, Anoop S. Singh, Nidhi Mishra, Anand K. Agrahari, Vinod K. Tiwari
Benzotriazole has been established as an efficient ligand in Cu-catalyzed cross-coupling of terminal alkynes to form 1,3-dialkynes using CuI as the catalyst and K2CO3 as the base at room temperature in an open round-bottom flask. The established protocol has the following notable advantages: simple to handle, easy work-up, mild reaction condition, high substrate scope, requirement of less quantity of ligand and also Cu-catalyst, less expensive, and high reaction yield.

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